a regular pack pulls back on your shoulders and can damage your spine if you carry a load for an extended period of time. A frame pack transfers most of the weight to your hips. A 50lb load in a frame pack feels like a 15lb load in a non-frame pack.
The pack must be the right size and properly adjusted to work. If it is, you will never backpack with anything else again. You should only use a frame pack when carrying any significant load.
Go to a real outfitting store (like REI) and get them to measure your torso and make some recommendations. You don't have to buy from them, but you'll at least know what you're looking for.
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