Pickup truck if you can, 4x4 atv if the truck can't, and a horse if the 4x4 can't. Unless you have a herd of big strong sons, son-in-laws and grandsons like I do.
Carcass removal is definately something to think about before you pull that trigger or release that arrow. I have passed on a lot of big bucks and a lot of elk because they were in a place that would have been hard to get them out. We normally avoid hunting those kind of areas but sometimes you venture into a new place and know you don't want to pack an animal out of there.